Optiflow™ Nasal High Flow therapy | Fisher & Paykel Healthcare

An interview with
Dr. Jean-Pierre Frat

Nasal High Flow (NHF) - Clinical research and clinical practice

Dr. Jean-Pierre Frat, chief investigator of the landmark FLORALI study, talks to us about his experience as a researcher and clinician, reflecting on a decade of using NHF. We discuss the practical application of NHF for multiple applications in Acute Hypoxemic Respiratory Failure.

Watch the full interview now (22 mins)

Watch in bite-sized pieces (scroll down)

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Please note that this video/audio is intended for healthcare practitioners and the information conveyed does not constitute medical advice. This video/audio should not be used to replace individual hospital policies or practices. The matters expressed in this video/audio are presented by the speakers and do not necessarily represent the views of Fisher & Paykel Healthcare, or any of its employees, officers or directors. Dr. Frat receives payment from Fisher & Paykel Healthcare under a consultancy arrangement. Fisher & Paykel Healthcare also provides support to clinical studies in which Dr. Frat is involved.

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The interview in bite-sized pieces

What NHF settings do you start with and why?

(2 min 34 sec)

How do you monitor patients and make the decision to escalate?

(6 min 09 sec)

Dr Jean-Pierre Frat Approach to Weaning off NHF

What's your approach to weaning patients from NHF?

(1 min 44 sec)

Dr. Jean Frat - NHF in supporting intubation

The role of NHF in supporting intubation

(2 min 59 sec)

NHF for post-extubation support

(4 min 37 sec)

What next? Dr. Frat talks about a new 60-center study hoping to recruit 1,100 patients.

(1 min 52 sec)

Dr. Jean-Pierre Frat (MD, PhD) is currently working in the medical ICU at the University Hospital of Poitiers in France. He works within the ALIVE lab working on non-invasive strategies of oxygenation and sleep disorders in ICU patients. He has conducted several multicentre clinical trials in collaboration with the European network REVA assessing the impact of non-invasive respiratory therapies including the landmark FLORALI study. Currently, he is conducting another important clinical trial, the SOHO study which will assess conventional oxygen therapy and NHF in patients with acute hypoxemic respiratory failure.

Key clinical studies

These are some of the studies referenced by Dr. Frat during the interview

Frat et al. 2015. NEJM. aka the FLORALI study

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Further reading:
Pubmed abstract

Thille et al. 2019. JAMA. aka the HIGH-WEAN study

Download PDF

Further reading:
Pubmed abstract

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An interview with Dr. Jean-Pierre Frat