Clinical Outcomes

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Kaplain-Meier analysis of time from extubation to reintubation graph

'Use of NHF reduced the risk of reintubation within 72 hours.'

(among extubated patients at low risk for reintubation)

~ Hernández et al. JAMA. 2016.

PubMed abstract Download summary

Reduced 90 day mortality and reduced intubation rate graphs

NHF significantly reduced need for intubation in more acute patients

(compared to standard O₂ and NIV,
PaO₂:FiO₂ ≤ 200 mmHg)

~ Frat et al. New Engl J Med. 2015.

PubMed abstract Download summary

Medical staff with Nasal High Flow male patient

NHF was found
non-inferior to BPAP

(among cardiothoracic surgery patients with or at risk for respiratory failure)

~ Stéphan et al. JAMA. 2015

PubMed abstract Download summary

Reduces escalation of care

Pre-intubation:

Significantly reduces intubation rate when PaO₂:FiO₂ ≤200 mm Hg

Frat et al. New Engl
J Med. 2015.

Post-Extubation:

Reduces escalation to non-invasive ventilation and re-intubation

Parke et al. Respir
Care. 2011.
Hernández et al.
JAMA. 2016.

Non-inferior to Bi-level Positive Airway Pressure

Stéphan et al.
JAMA. 2015.

Improves symptomatic relief

Significantly reduced intensity of respiraotry discomfort and dyspnea

Frat et al. New Engl J
Med 2015.

Significantly less dyspnea compared with face mask
RespirRoca et al.
Care.2010.

Rapid and sustained improvement of dyspnea in patients with respiratory distress in the emergency department

Lenglet et al.
Respir Care. 2012.

Improves patient comfort

Well tolerated

Sztrymf et al. Intensive
Care Medicine. 2011.

Greater overall comfort than face mask

Roca et al.
Respir Care.2010.
Lenglet et al.
Respir Care. 2012.

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