Physiological Effects

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Reduces respiratory rate

Reduces respiratory rate in comparison with traditional oxygen therapy
Sztrymf et al. Intensive Care Medicine. 2011,
Corley et al. Br J Anaesth. 2011,
Roca et al. Respir Care 2010,
Lenglet et al. Respir Care. 2012,
Rittayamai et al. Respir Care. 2013.

Reduces respiratory rate in patients with heart failure
Roca et al. Journal of Critical Care. 2013.

Reduces respiratory rate in palliative patients
Peters et al. Respir Care. 2012.

Reduces carbon dioxide

Reduces rebreathing of CO₂
Möller et al. J Appl Physiol. 2015,

Reduces dead space ventilation
Mündel et al. J Appl Physiol. 2013.

Reduces arterial CO₂
Jeong et al. Am J Em Med. 2015.

Improves oxygenation

Delivers a prescribed FIO₂
Ritchie et al. Anaesth Intensive Care. 2011,
Improved oxygenation in patients with respiratory distress
Peters et al. Respir Care. 2013.
Sztrymf et al. Intensive Care Medicine. 2011.

Improves oxygenation compared with traditional oxygen therapy
Corley et al. Br J Anaesth. 2011.
Roca et al. Respir Care. 2010
Improved oxygenation during bronchoscopy
Lucangelo et al. Crit Care Res Pract. 2012.

"[Nasal High Flow] significantly reduced respiratory rate."

~ Sztrymf et al. Intensive Care Med. 2011.

PubMed abstract

Open summary

Increases tidal volume

Increases tidal volume compared with low-flow oxygen therapy
Corley et al. Br J Anaesth. 2011.

Increases end-expiratory lung volume

Increases airway pressure, which increases end-expiratory lung volume
Based on measurements of lung impedance.
Corley et al. Br J Anaesth. 2011.

Improves mucus clearance

Increases mucus clearance

Humidification therapy improves mucocillary clearance
Hasani et al. Chron Respir Dis. 2008.

Optiflow FAQs, related to physiological outcomes

Who does Nasal High Flow work on?

How much pressure is generated by Nasal High Flow?

What effect does low humidity have on the airway?

Take me to FAQs

Resources

Optiflow Adult Clinical Paper Summaries

(PDF 0.8MB)

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Optiflow Flow Matters Newsletter - Issue 8

(PDF 0.1MB)

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Optiflow Therapy Brochure

(PDF 0.9MB)

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