What Optiflow™ Means for
Clinical Practice

Evidence suggests that Optiflow Nasal High Flow (NHF)
therapy reduces escalation, reduces mortality rates,
improves symptomatic relief
and promotes compliance.

Large randomized controlled trials using Optiflow NHF therapy have
been published in some of the world's most prestigious medical journals.
Discover what Optiflow™ can do for your clinical practice.

Kaplain-Meier analysis of time from extubation to reintubation graph

'Use of NHF reduced the risk of reintubation within 72 hours.'

(among extubated patients at low risk for reintubation)

~ Hernández et al. JAMA. 2016.

Reduced 90 day mortality and reduced intubation rate graphs

NHF significantly reduced need for intubation in more acute patients

(compared to standard O2 and NIV,
PaO2:FiO2 ≤ 200 mmHg)

~ Frat et al. New Engl J Med. 2015.

Medical staff with Nasal High Flow male patient

NHF was found
non-inferior to BPAP

(among cardiothoracic surgery patients with or at risk for respiratory failure)

~ Stéphan et al. JAMA. 2015

Reduces escalation of care


  • Significantly reduces intubation rate when PaO2:FiO2 ≤200 mm Hg
         Frat et al. New Engl J Med. 2015.


  • Reduces escalation to non-invasive ventilation and re-intubation
         Maggiore et al. AJRCCM. 2014.
         Parke et al. Respir Care. 2011.
         Hernández et al. JAMA. 2016. 
  • Non-inferior to Bi-level Positive Airway Pressure
         Stéphan et al. JAMA. 2015.

Reduces mortality rate

  • Significantly reduces 90-day mortality
         Frat et al. New Engl J Med. 2015

Improves symptomatic relief

  • Significantly reduced intensity of respiraotry discomfort and dyspnea
         Frat et al. New Engl J Med 2015. 
  • Significantly less dyspnea compared with face mask          
         Roca et al. Respir Care.2010. 
  • Rapid and sustained improvement of dyspanea in patients with respiratory distress in the emergency department
         Lenglet et al. Respir Care. 2012. 


Improves comfort and patient compliance

  • Well tolerated
          Sztrymf et al. Intensive Care Medicine. 2011. 
  • Greater overall comfort than face mask
          Roca et al. Respir Care.2010. 
          Lenglet et al. Respir Care. 2012. 
  • Heating and humidification of gas improves patietn comfort and tolerance of therapy
         Maggiore et al. Am J Repir Crit Care Med. 2014
  • Significantly less skin breakdown than BPAP
         Stéphan et al. JAMA. 2015
  • Lower nurse workload noted, compared with BPAP
         Stéphan et al. JAMA 2015



Optiflow Adult Clinical Paper Summaries

(PDF 0.8MB)


Optiflow Therapy Brochure

(PDF 0.9MB)


Optiflow Flow Matters Newsletter - Issue 8

(PDF 0.1MB)


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