What Optiflow™ Means for
Clinical Practice

Evidence suggests that Optiflow Nasal High Flow (NHF) reduces escalation, reduces mortality rates, improves symptomatic relief and promotes compliance.

Large randomized controlled trials using Optiflow have been published in some of the world's most prestigious medical journals. Discover what Optiflow™ can do for your clinical practice.

'Use of NHF reduced the risk of reintubation within 72 hours.'

(among extubated patients at low risk for reintubation)

~ Hernández et al. JAMA. 2016.

NHF significantly reduced need for intubation in more acute patients

(compared to standard O2 and NIV,
PaO2:FiO2 ≤ 200 mmHg)

~ Frat et al. New Engl J Med. 2015.

NHF was found non-inferior to BPAP

(among cardiothoracic surgery patients with or at risk for respiratory failure)

~ Stéphan et al. JAMA. 2015


  • Significantly reduces intubation rate when PaO2:FiO2 ≤200 mm Hg
    Frat et al. New Engl J Med. 2015.


  • Reduces escalation to non-invasive ventilation and re-intubation
    Maggiore et al. AJRCCM. 2014.
    Parke et al. Respir Care. 2011.
    Hernández et al. JAMA. 2016. 

  • ​Non-inferior to Bi-level Positive Airway Pressure
    Stéphan et al. JAMA. 2015.

  • Significantly reduces 90-day mortality

Frat et al. New Engl J Med. 2015


  • Significantly reduced intensity of respiratory discomfort and dyspnea
    Frat et al. New Engl J Med. 2015.

  • Significantly less dyspnea compared with face mask
    Roca et al. Respir Care. 2010.

  • Rapid and sustained improvement of dyspnea in patients with respiratory distress in the emergency department
    Lenglet et al. Respir Care. 2012.
  • Well tolerated
    Sztrymf et al. Intensive Care Medicine. 2011.
  • Greater overall comfort than face mask
    Roca et al. Respir Care. 2010
    Lenglet H. et al. Respir Care. 2012.
  • Heating and humidification of gas improves patient comfort and tolerance of therapy
    Maggiore et al. Am J Respir Crit Care Med. 2014.
  • Significantly less skin breakdown than BPAP
    Stéphan et al. JAMA. 2015
  • Lower nurse workload noted, compared with BPAP
    Stéphan et al. JAMA. 2015

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Optiflow Therapy Brochure

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