Physiological Effects

The mechanisms of respiratory support, airway hydration, patient comfort and supplemental oxygen contribute to distinct physiological effects.

Reduces respiratory rate

Reduces respiratory rate

  • Reduces respiratory rate in comparison with traditional oxygen therapy
    Sztrymf et al. Intensive Care Medicine. 2011,
    Corley et al. Br J Anaesth. 2011,
    Roca et al. Respir Care 2010,
    Lenglet et al. Respir Care. 2012,
    Rittayamai et al.Respir Care. 2013.

  • Reduces respiratory rate in patients with heart failure
    Roca et al. Journal of Critical Care. 2013.

  • Reduces respiratory rate in palliative patients
    Peters et al. Respir Care. 2012.

  •  

Reduces carbon dioxide

Reduces carbon dioxide

  • Reduces rebreathing of CO2
    Möller et al. J Appl Physiol. 2015,

  • Reduces dead space ventilation
    Mündel et al. J Appl Physiol. 2013.

  • Reduces arterial CO2
    Jeong et al. Am J Em Med. 2015.

Improves oxygenation

Improves oxygenation

  • Delivers a prescribed FIO2
    Ritchie et al. Anaesth Intensive Care. 2011,
    Mascians et al. Clin Pulm Med. 2012.

  • Improved oxygenation in patients with respiratory distress
    Peters et al. Respir Care. 2013.
    Sztrymf et al. Intensive Care Medicine. 2011.

  • Improves oxygenation compared with traditional oxygen therapy
    Corley et al. Br J Anaesth. 2011.
    Roca et al. Respir Care. 2010
    Maggiore et al. Am J Respir Crit Care Med. 2012.

  • Improved oxygenation during bronchoscopy
    Lucangelo et al. Crit Care Res Pract. 2012.

"[Nasal High Flow] significantly reduced respiratory rate."

~ Sztrymf et al. Intensive Care Med. 2011.

Increases tidal volume

Increases tidal volume

  • Increases tidal volume compared with low-flow oxygen therapy
    Corley et al. Br J Anaesth. 2011.

Increases end-expiratory lung volume

Increases end-expiratory lung volume

  • Increases airway pressure, which increases end-expiratory lung volume
    Based on measurements of lung impedance.
    Corley et al. Br J Anaesth. 2011.

Improves mucus clearance

Increases mucus clearance

  • Humidification therapy improves mucocillary clearance
    Hasani et al. Chron Respir Dis. 2008.
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Resources

Optiflow Adult Clinical Paper Summaries

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Optiflow Therapy Brochure

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Optiflow Flow Matters Newsletter - Issue 8

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