Invasive Ventilation

Heated respiratory humidification to assist with secretion clearance during Invasive ventilation.

Invasive ventilation is a form of respiratory support that is delivered directly to the lower airways, such as by a tracheostomy tube. This means that the natural mechanisms of filtration, humidification and warming that are typically provided by the upper airways are bypassed.
  
Invasive respiratory support uses a ventilator to enable or support lung function and subsequent gas exchange.[1]
  
In the home, invasive long-term mechanical ventilation generally refers to patients who receive positive pressure ventilation via a tracheostomy tube.[1] Some of the most common indications for a tracheostomy include the requirement for prolonged mechanical ventilation to overcome upper airway obstructions and facilitate secretion management.[2]
  
The upper airway provides up to 75% of heat and humidity to inspired gas.[3] Therefore, the delivery of heated humidity for invasively ventilated patients in the home is crucial.

The benefits of heated humidification for patients with bypassed airways

The respiratory system is a highly balanced mechanism reliant on humidity.

Normal adult airway.

The respiratory system is a highly balanced mechanism reliant on humidity.[4] During normal inspiration, as air travels down the airway  heat and moisture are drawn from the airway mucosa until the gas reaches 37 °C, 44 mg/L H₂O close to the carina.[5,6]

 

Bypassed airways.

When the upper airway is bypassed, e.g., with a tracheostomy tube, the upper airway’s humidifying surfaces and filtering mechanisms are also bypassed. This compromises the protective cough, gag and sneeze reflexes.[7]

Complications associated with the failure to heat and humidify inspired gases for patients with bypassed airways include thickening of secretions, drying of the airway, airway obstruction (including blockage of artificial airways) and bronchospasm.[8]

 

Secretion clearance for efficient gas exchange and ventilation.

Secretion clearance is fundamental to limiting airway occlusion and promoting efficient ventilation and gas exchange. Humidification is integral to secretion management in mechanically ventilated patients [8] and it assists with secretion mobilization and removal.[3,9] Insufficient respiratory humidification can result in diminished cilia activity, decreased cilia beat frequency, ciliary destruction and cellular damage.[4] This can lead to increased mucus viscosity and impaired mucociliary clearance, which can cause secretion retention, with potential for airway occlusion and atelectasis.[4]

The respiratory system is a highly balanced mechanism reliant on humidity.

Supporting the natural defense mechanisms in the airway.

It is important for the airway mucosa to retain a balance of heat and moisture to maintain a fully functioning mucociliary transport system and an efficient line of defense. When mucus transport is inadequate, mucus can turn into a risk factor instead of a defense mechanism. Therefore, humidification and as-needed suctioning are the foundations of secretion management in mechanically ventilated patients.[8] Heated respiratory humidifiers can deliver a higher level of heat and humidity than heat and moisture exchangers (HMEs). Accordingly, they are the humidification method of choice for some patients.[3,8]


Persistent airway inflammation and mucus retention are also clinical problems in patients with chronic respiratory diseases, such as obstructive pulmonary disease and bronchiectasis. Homecare patients commonly use home ventilators where humidity can be used to improve secretion clearance.[10,11]

Related products and support resources

F&P 550 System (HC550)

Using the HC550 Respiratory Humidifier, a F&P humidification chamber and either RT Series or Evaqua Breathing circuits, the F&P 550 System provides humidification for invasive home ventilation.


Accessories:
 RT-series Breathing Circuits
 Evaqua 2 Breathing Circuits

Adult Invasive Ventilation Clinical Paper Summaries

F&P 550 System for Invasive Ventilation Brochure

HC550 Respiratory Humidifier User Instruction

References