Optiflow™ mechanisms of action

The mechanisms of action of Optiflow nasal high flow (NHF) therapy differs from those of conventional therapies, as do the resulting physiological effects and clinical outcomes.

The Optiflow NHF therapy mechanisms of action are:

 
Note: the above mechanisms apply to delivery via an Optiflow nasal cannula interface. The mechanisms of action differ when high flow is delivered through a tracheostomy or mask interface adapter.

 
Optiflow Mechanisms

 

Reduction of dead space



Clearance of expired air in the upper airways reduces rebreathing of gas high in CO2 and depleted O2, increasing alveolar ventilation.

Dynamic, positive airway pressure



NHF creates breath and flow-dependent pressure, making inspiration
easier and promoting slow, deep breathing on expiration,
thereby increasing alveolar ventilation.

Airway hydration/heated humidification



Humidity enables the comfortable delivery of high flows of gas.  
Optimized humidity emulates the natural balance of heat and moisture in healthy lungs and may promote physiological stability in compromised airways.  

Patient comfort


Respiratory support delivered via a mask poses challenges for clinicians and patients.
NHF delivered via a cannula promotes patient comfort and may improve compliance.

Supplemental oxygen (if required)



If oxygen is prescribed, delivering it via NHF gives you some confidence in the accurate delivery of blended, humidified oxygen.

How does NHF compare with COT?

Although an NHF device can deliver high oxygen levels (up to 100% FiO2), it’s not specifically an oxygen delivery device. NHF can be, and is, often used without supplemental oxygen, i.e., with room air – 0.21 FiO2.

Conventional oxygen therapy via a low-flow cannula and most styles of oxygen face masks are limited to lower flow rates (up to 10 L/min) partly because the gas is cold and dry, making tolerability a significant issue.

These lower flow rates also limit FiO2 delivery and accuracy and aren’t high enough to offer the benefits of dead-space washout and positive airway pressure.

Typically, “high flow” refers to flow rates above 15 L/min of a fully humidified air and oxygen mix. These higher flow rates enable mechanisms that cold, dry oxygen alone cannot provide.

See the table below for a comparison of standard COT devices and NHF.

Optiflow Nasal High Flow compared with traditional oxygen delivery systems


 

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